Bottom fragger5/15/2023 ![]() On the other hand, the main drugs associated with these proteins are potassium persulfate, aluminum, and cadmium. We also identified three microRNAs that highly restrict the expression of these proteins: hsa-mir-124-3p, hsa-mir-27a-3p, and hsa-mir-26b-5p. We found three transcription factors that regulate most of the genes of these proteins: TFDP1, SOX13, and BCL6. These proteins show enrichment in antioxidant activity, antimicrobial response, immune response, and vitamin and mineral metabolism. In the literature search, we extracted 26 differentially expressed proteins. This research aims to identify and integrate the main differentially expressed proteins in the saliva of children with caries, infer their Gene Ontology and interactions, and identify regulatory factors. We analyzed these proteins with the web application ShinyGO v0.76, ToppGene and NetworkAnalyst 3.0, and the Cytoscape platform. ![]() We extracted proteins from a bibliographic search in the Scopus and PubMed databases. Proteomics allows us to analyze and identify many proteins in a single sample and a single experiment bioinformatics is essential to analyze proteomic data. Objective: This research aims to identify and integrate the main differentially expressed proteins in the saliva of children with caries, infer their Gene Ontology and interactions, and identify regulatory factors.ĭental caries can affect the expression of salivary proteins. Proteomics allows us to analyze and identify many proteins in a single sample and experiment bioinformatics is essential to analyze proteomic data. As you’ve probably figured out by now, if someone is bottom fragging, it means they’re at the lowest part of the scoreboard, having the lowest possible KDA ratio in his team/on the server.Dental caries can affect the expression of salivary proteins. His KDA ratio is the best, therefore he’s top fragging since he’s on top of the scoreboard.īottom fragging is the opposite. When one player is top fragging on his team or on the server in general, it means he is the best player in terms of individual statistics. And, frankly speaking, both of them are quite self-explanatory. In regard to player standings in the scoreboard of every match, there are basically no other sayings than top fragging and bottom fragging. What do top fragging and bottom fragging mean in CS:GO? ![]() Regarding the latter, though, the explanation is much simpler. When it comes to the former, you might often pop into terms like support player or in-game leader. There are, obviously, some terms that touch on players’ positions both in-game strategy-wise, and how they place in the standings. Some of them, like banana, point to certain places on maps, others, like eco or deep smoke, are callouts to strategy for one round and throwing a one-of-a-kind grenade, respectively. Therefore, since strategy is such a big deal in CS:GO especially, the best matchmaking players and the pros need to memorize more than a hundred terms. If you don’t have a plan for the round or the map overall, no matter how good you are playing, in most cases you should still be disarmed by the enemy team, given that they’re better prepared. Like every esports game, while personal skill and mechanics are hugely important, strategy always comes first, and it’s no different in Counter-Strike. With an esports title as advanced as CS:GO, it should be to no one’s surprise that it has a number of different terms. ![]()
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